872717-97-0
872717-97-0 structure
- Name: KISS1-305
- Chemical Name: KISS1-305
- CAS Number: 872717-97-0
- Molecular Formula: C56H76N16O12
- Molecular Weight: 1165.30
- Catalog: Research Areas Others
- Create Date: 2020-04-10 20:15:06
- Modify Date: 2024-04-09 10:20:35
-
KISS1-305, the Metastin/Kisspeptin analog, is a prototype peptide and a chemical probe. KISS1-305 has suboptimal KISS1R agonistic activity, and resists plasma protease degradation[1].
| Name | KISS1-305 |
|---|
| Description | KISS1-305, the Metastin/Kisspeptin analog, is a prototype peptide and a chemical probe. KISS1-305 has suboptimal KISS1R agonistic activity, and resists plasma protease degradation[1]. |
|---|---|
| Related Catalog | |
| In Vivo | KISS1-305 (4 nmol/h; s.c.) shows suppression of pituitary-gonadal functions[1]. KISS1-305 causes substantial elevations of plasma LH and testosterone, followed by abrupt reductions of both hormone levels. KISS1-305 also reduced genital organ weight more profoundly than leuprolide. In mechanistic studies, chronic KISS1-305 administration only transiently induced c-Fos expression in GnRH neurons, suggesting that GnRH-neural response was attenuated over time[1]. Animal Model: Adult male Sprague Dawley Crl:CD(SD) rats (8-10 wk of age)[1] Dosage: 4 nmol/h Administration: s.c. Result: Both plasma T and LH levels were markedly increased on d 1 after the initiation of dosing and dramatically decreased thereafter to the lower limit of detection (LH: 0.08 ng/ml; T: 0.04 ng/ml) by d 6. |
| References |
| Molecular Formula | C56H76N16O12 |
|---|---|
| Molecular Weight | 1165.30 |