610753-87-2
610753-87-2 structure
- Name: KIN101
- Chemical Name: KIN101
- CAS Number: 610753-87-2
- Molecular Formula: C16H11BrO5S
- Molecular Weight: 395.22
- Catalog: Signaling Pathways Anti-infection HCV
- Create Date: 2020-04-21 18:51:52
- Modify Date: 2024-01-11 19:13:53
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KIN101 is a potent RNA viral inhibitor with IC50s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively. KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has broad-spectrum activity against RNA viruses[1][2].
| Name | KIN101 |
|---|
| Description | KIN101 is a potent RNA viral inhibitor with IC50s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively. KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has broad-spectrum activity against RNA viruses[1][2]. |
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| Related Catalog | |
| Target |
IC50: 2 μM (influenza virus) and >5 μM (DNV)[1] |
| In Vitro | KIN 101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance[1]. KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels[1]. KIN 101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC50 of 0.2 μM[1]. KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells[1]. KIN 101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5[1]. KIN101 (0.1-100 μM; 18 hours) shows the antiviral activity against hepatitis C virus (HCV)[2]. Western Blot Analysis[1] Cell Line: MRC5 cells Concentration: 10 μM Incubation Time: 24 hours Result: Caused a significant decrease in the NP protein abundance. RT-PCR[1] Cell Line: Huh7 cells Concentration: 10 μM Incubation Time: 18 hours Result: Showed a >1 log decrease in HCV RNA levels. |
| References |
| Molecular Formula | C16H11BrO5S |
|---|---|
| Molecular Weight | 395.22 |