2407981-35-3
2407981-35-3 structure
- Name: FM26
- Chemical Name: FM26
- CAS Number: 2407981-35-3
- Molecular Formula: C22H15ClF3N3O3
- Molecular Weight: 461.82
- Catalog: Signaling Pathways Metabolic Enzyme/Protease ROR
- Create Date: 2020-04-05 09:07:02
- Modify Date: 2025-08-20 12:19:32
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FM26 (compound 25) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM. FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells[1].
| Name | FM26 |
|---|
| Description | FM26 (compound 25) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM. FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells[1]. |
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| Related Catalog | |
| Target |
IC50: 264 nM (RORγt)[1] |
| In Vitro | FM26 (compound 25; 10 μM, 24h) significantly reduces IL-17a mRNA expression 27-fold in EL4 cells[1]. |
| References |
| Molecular Formula | C22H15ClF3N3O3 |
|---|---|
| Molecular Weight | 461.82 |