1542098-94-1
1542098-94-1 structure
- Name: DHQZ 36
- Chemical Name: DHQZ 36
- CAS Number: 1542098-94-1
- Molecular Formula: C21H18F2N2OS
- Molecular Weight: 384.44
- Catalog: Research Areas Infection
- Create Date: 2020-04-29 22:31:36
- Modify Date: 2024-01-08 18:10:24
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DHQZ 36 is a potent inhibitor of retrograde trafficking. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages with an EC50 of 13.63 μM. DHQZ 36 has potent anti-parasite activity[1].
| Name | DHQZ 36 |
|---|
| Description | DHQZ 36 is a potent inhibitor of retrograde trafficking. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages with an EC50 of 13.63 μM. DHQZ 36 has potent anti-parasite activity[1]. |
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| Related Catalog | |
| Target |
EC50: 13.63 μM (Leishmania amazonensis)[1] |
| In Vitro | With increasing concentrations of DHQZ 36 there is a significant diminution in the size of parasitophorous vacuoles (LPVs), vacuole sizes are reduced by 30% at 50 μM. These parasites also cause a reduction in the number of parasites per macrophage. Significant parasite loss is observed with as low as 5 μM after treatment with DHQZ 36. Parasites are unable to recover growth when treated with DHQZ 36 at concentrations at or above 12.5 μM[1]. DHQZ 36 causes over 40% reduction in secreted of parasite proteins. DHQZ 36 causes a reversal in Leishmania induced suppression of IL-6 release by infected cells after LPS activation[1]. |
| References |
| Molecular Formula | C21H18F2N2OS |
|---|---|
| Molecular Weight | 384.44 |