883098-58-6
883098-58-6 structure
- Name: CCT129957
- Chemical Name: CCT129957
- CAS Number: 883098-58-6
- Molecular Formula: C17H15N3O3
- Molecular Weight: 309.32
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
- Create Date: 2020-04-27 18:06:23
- Modify Date: 2024-01-11 09:56:41
-
CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of ~3 μM and a GC50 of 15 μM. CCT129957 inhibits Ca2+ release in squamous carcinoma cells at ~15 μM[1][2].
| Name | CCT129957 |
|---|
| Description | CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of ~3 μM and a GC50 of 15 μM. CCT129957 inhibits Ca2+ release in squamous carcinoma cells at ~15 μM[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: ~3 μM (Phospholipase C-γ (PLC-γ))[1] |
| In Vitro | The phenyl group on the left side sat in a lipophilic pocket formed of various amino acids. The predicted binding mode of CCT129957 displays a robust hydrogen bond pattern as well as a lipophilic contact[1]. CCT129957 inhibits the cell growth of renal UO-31 and the breast T-47D cancer cell lines by ~60-70%[2]. |
| References |
| Molecular Formula | C17H15N3O3 |
|---|---|
| Molecular Weight | 309.32 |
| Hazard Codes | Xi |
|---|