1902954-87-3
1902954-87-3 structure
- Name: Abeprazan hydrochloride
- Chemical Name: Abeprazan hydrochloride
- CAS Number: 1902954-87-3
- Molecular Formula: C19H18ClF3N2O3S
- Molecular Weight: 446.87
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Proton Pump
- Create Date: 2020-04-05 12:57:37
- Modify Date: 2025-08-26 18:38:05
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Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan hydrochloride is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases[1].
| Name | Abeprazan hydrochloride |
|---|
| Description | Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan hydrochloride is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases[1]. |
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| Related Catalog | |
| In Vitro | The mechanism of action of Abeprazan hydrochloride is reversibly binding to H+, K+‐ATPase, and, unlike that of PPIs, does not require acidic environment for drug activation[1]. |
| In Vivo | Abeprazan hydrochloride (DWP14012 hydrochloride) inhibits acid secretion in a dose-dependent manner and the inhibition of gastric acid secretion is equal to or greater than that of vonoprazan, a previously approved P-CAB, in various in vivo studies using pylorus-ligated rats, lumen-perfused rat models and heidenhain pouch dog models[1]. |
| References |
| Molecular Formula | C19H18ClF3N2O3S |
|---|---|
| Molecular Weight | 446.87 |