2301866-59-9
2301866-59-9 structure
- Name: DO-264
- Chemical Name: 1-(1-{3-Chloro-4-[2-chloro-4-(trifluoromethoxy)phenoxy]-2-pyridinyl}-4-piperidinyl)-3-(3-pyridinyl)thiourea
- CAS Number: 2301866-59-9
- Molecular Formula: C23H20Cl2F3N5O2S
- Molecular Weight: 558.403
- Create Date: 2020-02-10 20:03:13
- Modify Date: 2024-01-23 16:35:18
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DO264 is an inhibitor of α/β-hydrolase domain-containing protein 12 (ABHD12; IC50 = 11 nM).It inhibits ABHD12-dependent hydrolysis of lysophosphatidylserine (lyso-PS) in mouse brain membrane lysates (IC50 = 2.8 nM) and human THP-1 cells.
| Name | 1-(1-{3-Chloro-4-[2-chloro-4-(trifluoromethoxy)phenoxy]-2-pyridinyl}-4-piperidinyl)-3-(3-pyridinyl)thiourea |
|---|---|
| Synonyms |
Thiourea, N-[1-[3-chloro-4-[2-chloro-4-(trifluoromethoxy)phenoxy]-2-pyridinyl]-4-piperidinyl]-N'-3-pyridinyl-
1-(1-{3-Chloro-4-[2-chloro-4-(trifluoromethoxy)phenoxy]-2-pyridinyl}-4-piperidinyl)-3-(3-pyridinyl)thiourea |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 601.5±65.0 °C at 760 mmHg |
| Molecular Formula | C23H20Cl2F3N5O2S |
| Molecular Weight | 558.403 |
| Flash Point | 317.6±34.3 °C |
| Exact Mass | 557.066711 |
| LogP | 5.44 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.653 |