1628752-83-9

1628752-83-9 structure

Name: PD 0332991-d8
Chemical Name: Palbociclib D8
CAS Number: 1628752-83-9
Molecular Formula: C₂₄H₂₁D₈N₇O₂
Molecular Weight: 455.58
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2020-01-23 18:42:51
Modify Date: 2025-08-26 16:53:24
Palbociclib D8 (PD 0332991 D8) is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM, respectively. Palbociclib has no activity against other protein kinases. Palbociclib has potently anticancer activities[1].

Name	Palbociclib D8

Description	Palbociclib D8 (PD 0332991 D8) is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM, respectively. Palbociclib has no activity against other protein kinases. Palbociclib has potently anticancer activities[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	Cdk4/cyclin D3:9 nM (IC50) Cdk4/cyclin D1:11 nM (IC50) Cdk6/cyclin D2:16 nM (IC50) DYRK1A:2000 nM (IC50) MAPK:8000 nM (IC50)
References	[1]. Fry DW, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004 Nov;3(11):1427-38.