1330180-22-7

1330180-22-7 structure

Name: Nimesulide D5
Chemical Name: Nimesulide D5
CAS Number: 1330180-22-7
Molecular Formula: C₁₃H₇D₅N₂O₅S
Molecular Weight: 313.34
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2020-01-23 16:55:51
Modify Date: 2025-09-20 15:39:33
Nimesulide D5 is a deuterium labeled Nimesulide. Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties[1][2].

Name	Nimesulide D5

Description	Nimesulide D5 is a deuterium labeled Nimesulide. Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-2:0.07-70 μM (IC50)
References	[1]. Vago T, et al. Effect of nimesulide action time dependence on selectivity towards prostaglandin G/H synthase/cyclooxygenase activity. Arzneimittelforschung. 1995 Oct;45(10):1096-8. [2]. Werner MF, et al. Nimesulide-induced antipyresis in rats involves both cyclooxygenase-dependent and independent mechanisms. Eur J Pharmacol. 2006 Aug 14;543(1-3):181-9.

Molecular Formula	C₁₃H₇D₅N₂O₅S
Molecular Weight	313.34

Hazard Codes	Xi