1254980-38-5
1254980-38-5 structure
- Name: JNJ-46281222
- Chemical Name: JNJ-46281222
- CAS Number: 1254980-38-5
- Molecular Formula: C23H25F3N4
- Molecular Weight: 414.47
- Catalog: Signaling Pathways GPCR/G Protein mGluR
- Create Date: 2020-01-23 14:51:51
- Modify Date: 2024-01-10 18:03:01
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JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71)[1].
| Name | JNJ-46281222 |
|---|
| Description | JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71)[1]. |
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| Related Catalog | |
| Target |
mGluR2:1.7 nM (Kd) |
| In Vitro | JNJ‐4628122 binds to the selected mGlu2 receptor mutants is significantly decreased by approximately 10‐fold compared with WT, in transfected mGlu2 WT and mutant receptors in CHO‐K1 cells, mutations F643A and N735D are selected[1]. Western Blot Analysis[1] Cell Line: CHO‐K1 cells Concentration: Incubation Time: Result: Showed a decreased expression of mGlu2 receptor in mutant cells. |
| References |
| Molecular Formula | C23H25F3N4 |
|---|---|
| Molecular Weight | 414.47 |