277748-59-1

277748-59-1 structure

Name: CCP peptide
Chemical Name: CCP peptide
CAS Number: 277748-59-1
Molecular Formula: C₈₇H₁₄₅N₄₁O₃₂S₂
Molecular Weight: 2341.47
Catalog: Research Areas Inflammation/Immunology
Create Date: 2020-01-23 12:26:51
Modify Date: 2025-08-25 11:24:03
CCP peptide is a synthetic cyclic citrullinated peptide (CCP) and used as the substrate for detecting anti-CCP antibodies serologically. CCP peptide functions as a target for autoantibodies with a very high specificity for rheumatoid arthritis (RA)[1][2].

Name	CCP peptide

Description	CCP peptide is a synthetic cyclic citrullinated peptide (CCP) and used as the substrate for detecting anti-CCP antibodies serologically. CCP peptide functions as a target for autoantibodies with a very high specificity for rheumatoid arthritis (RA)[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vivo	CCP peptide is used as a new antigenic substrate in anti-CCP ELISA to detect anti-citrullinated protein antibodies (ACPAs). The anti-CCP ELISA is extremely specific (98%), with a reasonable sensitivity (68%). The anti-CCP ELISA is very useful for diagnostic and therapeutic strategies in rheumatoid arthritis (RA)[3].
References	[1]. Puszczewicz M, et al. Role of anti-citrullinated protein antibodies in diagnosis and prognosis of rheumatoid arthritis. Arch Med Sci. 2011 Apr;7(2):189-94. [2]. Söderlin MK, et al. Antibodies against cyclic citrullinated peptide (CCP) and levels of cartilage oligomeric matrix protein (COMP) in very early arthritis: relation to diagnosis and disease activity. Scand J Rheumatol. 2004;33(3):185-8. [3]. Schellekens GA, et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum. 2000 Jan;43(1):155-63.