1202764-53-1
1202764-53-1 structure
- Name: B022
- Chemical Name: B022
- CAS Number: 1202764-53-1
- Molecular Formula: C19H16ClN5OS
- Molecular Weight: 397.88
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2020-01-23 13:07:51
- Modify Date: 2024-09-23 09:02:21
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B022 is a potent and selective NF-κB-inducing kinase (NIK) inhibitor with a Ki of 4.2 nM. B022 protects liver from toxin-induced inflammation, oxidative stress, and injury[1].
| Name | B022 |
|---|
| Description | B022 is a potent and selective NF-κB-inducing kinase (NIK) inhibitor with a Ki of 4.2 nM. B022 protects liver from toxin-induced inflammation, oxidative stress, and injury[1]. |
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| Related Catalog | |
| Target |
Ki: 4.2 nM (NF-κB-inducing kinase (NIK))[1] |
| In Vitro | B022 (0-5 μM; 12 hours; Hepa1 cells) treatment suppresses NIK-induced p52 formation in a dose-dependent manner[1]. B022 (0-5 μM; 12 hours; Hepa1 cells) treatment for 8 h completely blocks NIK-induced expression of TNF-a, IL-6, iNOS, CCL2, and CXCL5[1]. Western Blot Analysis[1] Cell Line: Hepa1 cells Concentration: 0 μM, 0.5 μM, 5 μM Incubation Time: 12 hours Result: Suppressed NIK-induced p52 formation in a dose-dependent manner. RT-PCR[1] Cell Line: Hepa1 cells Concentration: 0 μM, 0.5 μM, 5 μM Incubation Time: 12 hours Result: Dose-dependently blocked NIK-induced expression of chemokines, cytokines, and iNOS in these cells. Completely blocked NIK-induced expression of TNF-a, IL-6, iNOS, CCL2, and CXCL5. |
| In Vivo | B022 (30 mg/kg; intravenous injection; twice a day; for 10 days; STOP-NIK male mice) treatment inhibits NIK-triggered liver inflammation and injury in STOP-NIK mice infected with cre adenoviruses[1]. Animal Model: STOP-NIK male mice (8 weeks) infected with Ad-cre[1] Dosage: 30 mg/kg Administration: Intravenous injection; twice a day; for 10 days Result: Completely prevents the lethal effect of abnormally high levels of hepatic NIK in mice. Inhibited the majority of the deteriorating effects of aberrant activation of hepatic NIK. |
| References |
| Molecular Formula | C19H16ClN5OS |
|---|---|
| Molecular Weight | 397.88 |