931417-26-4
931417-26-4 structure
- Name: ANI-7
- Chemical Name: ANI-7
- CAS Number: 931417-26-4
- Molecular Formula: C13H8Cl2N2
- Molecular Weight: 263.121
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Checkpoint Kinase (Chk)
- Create Date: 2020-01-11 19:33:50
- Modify Date: 2024-01-08 19:53:42
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A potent and selective (up to 263-fold) inhibitor of breast cancer cells with GI50 of 0.5 uM (MCF-7), via activation the aryl hydrocarbon receptor (AhR) pathway; inhibits other cell lines derived from other tumour types with GI50 of 3.2-46 uM (lung, colon, ovary, neuronal, glial, prostate, and pancreas); potently inhibits the growth of T47D, ZR-75-1, MCF-7, SKBR3, and MDA-MB-468 breast cancer cells with GI50 of 0.16-0.38 uM, induces cell cycle arrest checkpoint activation and DNA damage; binds to the AhR, induces translocation to the nucleus, activates the XRE, induces CYP1 activity, culminating in cell cycle arrest, checkpoint activation, DNA damage and cell death.
| Name | ANI-7 |
|---|
| Description | A potent and selective (up to 263-fold) inhibitor of breast cancer cells with GI50 of 0.5 uM (MCF-7), via activation the aryl hydrocarbon receptor (AhR) pathway; inhibits other cell lines derived from other tumour types with GI50 of 3.2-46 uM (lung, colon, ovary, neuronal, glial, prostate, and pancreas); potently inhibits the growth of T47D, ZR-75-1, MCF-7, SKBR3, and MDA-MB-468 breast cancer cells with GI50 of 0.16-0.38 uM, induces cell cycle arrest checkpoint activation and DNA damage; binds to the AhR, induces translocation to the nucleus, activates the XRE, induces CYP1 activity, culminating in cell cycle arrest, checkpoint activation, DNA damage and cell death. |
|---|---|
| References | References 1. Gilbert J, et al. Mol Pharmacol. 2017 Dec 21. pii: mol.117.109827. View Related Products by Target Aryl hydrocarbon Receptor (AhR) |
| Molecular Formula | C13H8Cl2N2 |
|---|---|
| Molecular Weight | 263.121 |