2226257-92-5
2226257-92-5 structure
- Name: NS-062
- Chemical Name: NS-062
- CAS Number: 2226257-92-5
- Molecular Formula: C28H30Cl2F2N6O4
- Molecular Weight: 623.483
- Create Date: 2020-01-12 11:29:41
- Modify Date: 2023-01-14 16:09:21
-
NS-062 (NS062) is a novel, specific targeted covalent inhibitor that shows high reactivity toward Cys797 of EGFR; showed higher target specificity for EGFR than the corresponding Michael acceptors in a wide concentration range (0.1-10 μM); showed strong antiproliferative activity (IC50=0.19 μM) against erlotinib-resistant H1975 cells (L858R T790M doublemutant EGFR), NS-062 effectively inhibited EGFR (Y1068) autophosphorylation in H1975 cells at 0.5 uM, significantly suppressed tumor growth in a mouse xenograft model after oral administration.
| Name | NS-062 |
|---|
| Description | NS-062 (NS062) is a novel, specific targeted covalent inhibitor that shows high reactivity toward Cys797 of EGFR; showed higher target specificity for EGFR than the corresponding Michael acceptors in a wide concentration range (0.1-10 μM); showed strong antiproliferative activity (IC50=0.19 μM) against erlotinib-resistant H1975 cells (L858R T790M doublemutant EGFR), NS-062 effectively inhibited EGFR (Y1068) autophosphorylation in H1975 cells at 0.5 uM, significantly suppressed tumor growth in a mouse xenograft model after oral administration. |
|---|---|
| References | References 1. Shindo N, et al. Nat Chem Biol. 2019 Jan 14. doi: 10.1038/s41589-018-0204-3. View Related Products by Target EGFR |
| Molecular Formula | C28H30Cl2F2N6O4 |
|---|---|
| Molecular Weight | 623.483 |