2151937-80-1
2151937-80-1 structure
- Name: AVG-233
- Chemical Name: AVG-233
- CAS Number: 2151937-80-1
- Molecular Formula: C26H22ClN5O3
- Molecular Weight: 487.944
- Catalog: Signaling Pathways Anti-infection RSV
- Create Date: 2020-01-11 17:12:50
- Modify Date: 2024-09-16 19:19:16
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AVG-233 (AVG233) is a potent, allosteric inhibitor of respiratory syncytial virus (RSV) RNA-dependent RNA polymerase (RdRp) complex, demonstrates nanomolar activity against both laboratory-adapted RSV strains and clinical RSV isolates (EC50=34-79 nM); exhibits 34% oral bioavailability and sustained high drug levels in the circulation after a single oral dose of 20 mg/kg.
| Name | AVG-233 |
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| Description | AVG-233 (AVG233) is a potent, allosteric inhibitor of respiratory syncytial virus (RSV) RNA-dependent RNA polymerase (RdRp) complex, demonstrates nanomolar activity against both laboratory-adapted RSV strains and clinical RSV isolates (EC50=34-79 nM); exhibits 34% oral bioavailability and sustained high drug levels in the circulation after a single oral dose of 20 mg/kg. |
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| References | References 1. Cox RM, et al. J Biol Chem. 2018 Oct 26;293(43):16761-16777. View Related Products by Target RSV |
| Molecular Formula | C26H22ClN5O3 |
|---|---|
| Molecular Weight | 487.944 |