2143542-28-1
2143542-28-1 structure
- Name: 2BAct
- Chemical Name: 2BAct
- CAS Number: 2143542-28-1
- Molecular Formula: C19H16ClF3N4O3
- Molecular Weight: 440.807
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Eukaryotic Initiation Factor (eIF)
- Create Date: 2020-01-20 11:14:56
- Modify Date: 2024-01-04 09:19:27
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2BAct (eIF2B activator 2BAct) is a novel, highly selective, CNS-permeable small molecule eIF2B activator with EC50 of 33 nM in cell-based reporter assays; 2BAct normalized body weight gain and prevented motor deficits in male R191H mice, prevented myelin loss and reactive gliosis in the brain and spinal cord of R191H mice; also prevented ISR induction in the cerebellum and spinal cord of Eif2b5R132H/R132H mice, prevented all measures of pathology and normalizes the transcriptome and proteome of Vanishing White Matter (VWM) mice.
| Name | 2BAct |
|---|
| Description | 2BAct (eIF2B activator 2BAct) is a novel, highly selective, CNS-permeable small molecule eIF2B activator with EC50 of 33 nM in cell-based reporter assays; 2BAct normalized body weight gain and prevented motor deficits in male R191H mice, prevented myelin loss and reactive gliosis in the brain and spinal cord of R191H mice; also prevented ISR induction in the cerebellum and spinal cord of Eif2b5R132H/R132H mice, prevented all measures of pathology and normalizes the transcriptome and proteome of Vanishing White Matter (VWM) mice. |
|---|---|
| References | References 1. Wong YL, et al. Elife. 2019 Jan 9;8. pii: e42940. doi: 10.7554/eLife.42940. View Related Products by Target Eukaryotic Initiation Factor (eIF) |
| Molecular Formula | C19H16ClF3N4O3 |
|---|---|
| Molecular Weight | 440.807 |