2101208-44-8
2101208-44-8 structure
- Name: CM03
- Chemical Name: CM03
- CAS Number: 2101208-44-8
- Molecular Formula: C34H44N6O6
- Molecular Weight: 632.762
- Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
- Create Date: 2020-01-20 17:04:56
- Modify Date: 2024-02-25 16:30:24
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CM03 is a G-quadruplex-binding compound that potently inhibits cell growth in PDAC cell lines (MIA PaCa-2 IC50=19 nM); CM03 shows >20-fold selectivity for MIA PaCa-2 compared to MCF-7 cells, also shows greater selectivity than MM41 relative to the non-oncogenic control fibroblasts; demonstrates anticancer activity in PDAC models, with a superior profile compared to gemcitabine.
| Name | CM03 |
|---|
| Description | CM03 is a G-quadruplex-binding compound that potently inhibits cell growth in PDAC cell lines (MIA PaCa-2 IC50=19 nM); CM03 shows >20-fold selectivity for MIA PaCa-2 compared to MCF-7 cells, also shows greater selectivity than MM41 relative to the non-oncogenic control fibroblasts; demonstrates anticancer activity in PDAC models, with a superior profile compared to gemcitabine. |
|---|---|
| References | References 1. Marchetti C, et al. J Med Chem. 2018 Feb 7. doi: 10.1021/acs.jmedchem.7b01781. View Related Products by Target DNA Alkylator/Crosslinker |
| Molecular Formula | C34H44N6O6 |
|---|---|
| Molecular Weight | 632.762 |