2089053-14-3
2089053-14-3 structure
- Name: DKR-1051
- Chemical Name: DKR-1051
- CAS Number: 2089053-14-3
- Molecular Formula: C24H26F3N
- Molecular Weight: 385.474
- Create Date: 2020-01-20 10:06:55
- Modify Date: 2022-10-07 19:32:23
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A novel potent, subtype-selective sigma 2 receptor/PGRMC1 ligand with Ki of 61 nM, 9-fold selectivity over sigma 1 receptors (Ki=556 nM); modulates intracellular Ca2+ levels in human SK-N-SH neuroblastoma cells, relieves spared nerve injury-induced mechanical hypersensitivity in vivo.
| Name | DKR-1051 |
|---|
| Description | A novel potent, subtype-selective sigma 2 receptor/PGRMC1 ligand with Ki of 61 nM, 9-fold selectivity over sigma 1 receptors (Ki=556 nM); modulates intracellular Ca2+ levels in human SK-N-SH neuroblastoma cells, relieves spared nerve injury-induced mechanical hypersensitivity in vivo. |
|---|---|
| References | References 1. Yi B, et al. J Neurochem. 2017 Feb;140(4):561-575. 2. Sahn JJ, et al. ACS Chem Neurosci. 2017 Aug 16;8(8):1801-1811. View Related Products by Target Sigma Receptor |
| Molecular Formula | C24H26F3N |
|---|---|
| Molecular Weight | 385.474 |