2043074-64-0
2043074-64-0 structure
- Name: ABX-1431 hydrochloride
- Chemical Name: ABX-1431 hydrochloride
- CAS Number: 2043074-64-0
- Molecular Formula: C20H23ClF9N3O2
- Molecular Weight: 543.859
- Create Date: 2020-01-12 11:01:51
- Modify Date: 2024-09-29 15:44:27
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ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL); displays 23-fold selectivity for MGLL versus ABHD6 and CES1c, as well as exquisite selectivity of against other members of the serine hydrolase class; inhibits MGLL activity in rodent brain (ED50=0.5-1.4 mg/kg), increases brain 2-AG concentrations, and suppresses pain behavior in the rat formalin pain model. Pain Phase 1 Clinical
| Name | ABX-1431 hydrochloride |
|---|
| Description | ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL); displays 23-fold selectivity for MGLL versus ABHD6 and CES1c, as well as exquisite selectivity of against other members of the serine hydrolase class; inhibits MGLL activity in rodent brain (ED50=0.5-1.4 mg/kg), increases brain 2-AG concentrations, and suppresses pain behavior in the rat formalin pain model. Pain Phase 1 Clinical |
|---|---|
| References | References 1. Cisar JS, et al. J Med Chem. 2018 Aug 1. doi: 10.1021/acs.jmedchem.8b00951. View Related Products by Target Monoacylglycerol Lipase (MAGL) Pain |
| Molecular Formula | C20H23ClF9N3O2 |
|---|---|
| Molecular Weight | 543.859 |