1957202-71-9
1957202-71-9 structure
- Name: YKL-1-116
- Chemical Name: YKL-1-116
- CAS Number: 1957202-71-9
- Molecular Formula: C34H38N8O3
- Molecular Weight: 606.731
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2020-01-14 11:47:08
- Modify Date: 2025-08-25 15:40:51
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YKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs; synergizes with 5-FU or nutlin-3 to kill HCT116 cells, produces dose-dependent increases in PARP cleavage; is more potent than THZ1 towards both Cdk7WT and Cdk7as (analog-sensitive mutant).
| Name | YKL-1-116 |
|---|
| Description | YKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs; synergizes with 5-FU or nutlin-3 to kill HCT116 cells, produces dose-dependent increases in PARP cleavage; is more potent than THZ1 towards both Cdk7WT and Cdk7as (analog-sensitive mutant). |
|---|---|
| References | References 1. Kalan S, et al. Cell Rep. 2017 Oct 10;21(2):467-481. View Related Products by Target Cyclin-dependent Kinase (CDK) |
| Molecular Formula | C34H38N8O3 |
|---|---|
| Molecular Weight | 606.731 |