1803427-24-8
1803427-24-8 structure
- Name: CK2 inhibitor D11
- Chemical Name: D11
- CAS Number: 1803427-24-8
- Molecular Formula: C20H13Cl2NO4
- Molecular Weight: 402.227
- Create Date: 2020-01-11 20:20:49
- Modify Date: 2025-08-25 04:07:03
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A potent, selective, cell permeab anti-apoptotic protein kinase CK2 with Ki of 5 nM; potently inhibits CK2α with IC50 of 7 nM, shows <2% remaining kinase activity against a panel of 354 eukaryotic protein kinases with exception of DYRK1B, PIM3 and IRAK1 (IC50=20-50 nM); inhibits the phosphorylation of the CK2 biomarker CDC37 at S13 in MIA PaCa-2 cells, also inhibits S380/T382/383 phosphorylation in PTEN in NSCLC cells.
| Name | D11 |
|---|
| Description | A potent, selective, cell permeab anti-apoptotic protein kinase CK2 with Ki of 5 nM; potently inhibits CK2α with IC50 of 7 nM, shows <2% remaining kinase activity against a panel of 354 eukaryotic protein kinases with exception of DYRK1B, PIM3 and IRAK1 (IC50=20-50 nM); inhibits the phosphorylation of the CK2 biomarker CDC37 at S13 in MIA PaCa-2 cells, also inhibits S380/T382/383 phosphorylation in PTEN in NSCLC cells. |
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| References | References 1. Guerra B, et al. Mol Cell Biochem. 2015 Aug;406(1-2):151-61. View Related Products by Target Casein Kinase |
| Molecular Formula | C20H13Cl2NO4 |
|---|---|
| Molecular Weight | 402.227 |