1803281-30-2
1803281-30-2 structure
- Name: BP-5-087
- Chemical Name: BP-5-087
- CAS Number: 1803281-30-2
- Molecular Formula: C36H30F8N2O6S
- Molecular Weight: 770.691
- Create Date: 2020-01-20 16:00:55
- Modify Date: 2023-01-13 14:16:23
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A potent, selective STAT3 SH2 domain inhibitor (EC50=5.6 uM) that reduces STAT3 phosphorylation and nuclear transactivation; restores TKI sensitivity to therapy-resistant CML progenitor cells in primary cells from CML patients with BCR-ABL1 kinase-independent TKI resistance, including leukemic stem cells.
| Name | BP-5-087 |
|---|
| Description | A potent, selective STAT3 SH2 domain inhibitor (EC50=5.6 uM) that reduces STAT3 phosphorylation and nuclear transactivation; restores TKI sensitivity to therapy-resistant CML progenitor cells in primary cells from CML patients with BCR-ABL1 kinase-independent TKI resistance, including leukemic stem cells. |
|---|---|
| References | References 1. Eiring AM, et al. Leukemia. 2015 Mar;29(3):586-597. 2. Eiring AM, et al. Leuk Suppl. 2014 Dec;3(Suppl 1):S5-6. View Related Products by Target STAT |
| Molecular Formula | C36H30F8N2O6S |
|---|---|
| Molecular Weight | 770.691 |