174766-49-5
174766-49-5 structure
- Name: XR 5118
- Chemical Name: XR 5118
- CAS Number: 174766-49-5
- Molecular Formula: C20H22ClN3O2S2
- Molecular Weight: 435.985
- Create Date: 2020-01-12 08:36:50
- Modify Date: 2025-08-25 14:09:39
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XR 5118 is a small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 3.5 uM, binds to PAI-1 and reduces plasma PAI-1 activity levels, promotes endogenous thrombolysis and inhibits thrombus accretion; the first nonpeptide compound with significant anti-PAI-1 activity in vivo. Thrombosis Discontinued
| Name | XR 5118 |
|---|
| Description | XR 5118 is a small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 3.5 uM, binds to PAI-1 and reduces plasma PAI-1 activity levels, promotes endogenous thrombolysis and inhibits thrombus accretion; the first nonpeptide compound with significant anti-PAI-1 activity in vivo. Thrombosis Discontinued |
|---|---|
| References | References 1. Friederich PW, et al. Circulation. 1997 Aug 5;96(3):916-21. 2. Einholm AP, et al. Biochem J. 2003 Aug 1;373(Pt 3):723-32. 3. Folkes A, et al. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2589-92. View Related Products by Target Plasminogen Activator Inhibitor-1 (PAI-1) Thrombosis |
| Molecular Formula | C20H22ClN3O2S2 |
|---|---|
| Molecular Weight | 435.985 |