1630804-27-1
1630804-27-1 structure
- Name: IQS-019 mesylate
- Chemical Name: IQS-019 mesylate
- CAS Number: 1630804-27-1
- Molecular Formula: C26H29Cl2N7O4S
- Molecular Weight: 606.523
- Create Date: 2020-01-19 21:03:56
- Modify Date: 2024-01-09 14:39:21
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A novel, potent inhibitor of most upstream tyrosine kinases in BCR signaling pathway, inhibits BCR kinases Lyn, Syk and Btk with IC50 of 0.15 uM, 1.6 uM and 2.1 uM, respectively; inhibits at least 20% of the kinase activity at 0.1 uM) and an almost complete kinase inactivation at the 10 uM in a set of 17 TK/TKLs; impaires cell proliferation, reduces CXCL12-dependent cell migration, and induces caspase-dependent apoptosis; shows improved efficacy in vitro and in vivo compared to ibrutinib.
| Name | IQS-019 mesylate |
|---|
| Description | A novel, potent inhibitor of most upstream tyrosine kinases in BCR signaling pathway, inhibits BCR kinases Lyn, Syk and Btk with IC50 of 0.15 uM, 1.6 uM and 2.1 uM, respectively; inhibits at least 20% of the kinase activity at 0.1 uM) and an almost complete kinase inactivation at the 10 uM in a set of 17 TK/TKLs; impaires cell proliferation, reduces CXCL12-dependent cell migration, and induces caspase-dependent apoptosis; shows improved efficacy in vitro and in vivo compared to ibrutinib. |
|---|---|
| References | References 1. Balsas P, et al. J Hematol Oncol. 2017 Mar 31;10(1):80. 2. Puig de la Bellacasa R, et al. Eur J Med Chem. 2014 Oct 30;86:664-75. View Related Products by Target BTK |
| Molecular Formula | C26H29Cl2N7O4S |
|---|---|
| Molecular Weight | 606.523 |