1467059-66-0
1467059-66-0 structure
- Name: PF-06679142
- Chemical Name: PF-06679142
- CAS Number: 1467059-66-0
- Molecular Formula: C20H17F2NO3
- Molecular Weight: 357.357
- Catalog: Signaling Pathways Epigenetics AMPK
- Create Date: 2020-01-20 01:08:56
- Modify Date: 2024-09-17 10:07:21
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PF-06679142 is a novel potent, orally active, α1β1γ1/α2β1γ1-isoform selective AMPK activator with Kd of 14 nM, EC50 of 22 nM for α1β1γ1-AMPK, shows minimal activity at the β2-containing isoforms (α1β2γ1, α2β2γ1, α2β2γ3); demonstrates in vivo target engagement experiment in ZSF-1 rats, an obese/diabetic rodent model of diabetic nephropathy.
| Name | PF-06679142 |
|---|
| Description | PF-06679142 is a novel potent, orally active, α1β1γ1/α2β1γ1-isoform selective AMPK activator with Kd of 14 nM, EC50 of 22 nM for α1β1γ1-AMPK, shows minimal activity at the β2-containing isoforms (α1β2γ1, α2β2γ1, α2β2γ3); demonstrates in vivo target engagement experiment in ZSF-1 rats, an obese/diabetic rodent model of diabetic nephropathy. |
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| References | References 1. Edmonds DJ, et al. J Med Chem. 2018 Feb 28. doi: 10.1021/acs.jmedchem.7b01641. View Related Products by Target AMPK |
| Molecular Formula | C20H17F2NO3 |
|---|---|
| Molecular Weight | 357.357 |