1345614-89-2
1345614-89-2 structure
- Name: AS1928370
- Chemical Name: AS1928370
- CAS Number: 1345614-89-2
- Molecular Formula: C29H31N3O2
- Molecular Weight: 453.586
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
- Create Date: 2020-01-11 23:11:49
- Modify Date: 2024-04-05 13:44:44
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AS1928370 (ASP8370) is a potent, selective, orally available TRPV1 antagonist with IC50 of 0.51 uM, shows no inhibitory effects on TRPV4, TRPA11, and TRPM8 at 10 uM; demonstrates high aqueous solubility (pH6.8, >100 uM), satisfactory stability in human liver microsomes, and reduced CYP3A4 inhibition; improves capsaicin-induced secondary hyperalgesia and mechanical allodynia in an L5/L6 spinal nerve ligation model in rats with respective ED50s of 0.17 and 0.26 mg/kg p.o.
| Name | AS1928370 |
|---|
| Description | AS1928370 (ASP8370) is a potent, selective, orally available TRPV1 antagonist with IC50 of 0.51 uM, shows no inhibitory effects on TRPV4, TRPA11, and TRPM8 at 10 uM; demonstrates high aqueous solubility (pH6.8, >100 uM), satisfactory stability in human liver microsomes, and reduced CYP3A4 inhibition; improves capsaicin-induced secondary hyperalgesia and mechanical allodynia in an L5/L6 spinal nerve ligation model in rats with respective ED50s of 0.17 and 0.26 mg/kg p.o. |
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| References | References 1. Oka H, et al. Bioorg Med Chem. 2018 Jul 23;26(12):3716-3726. 2. Watabiki T, et al. J Pharmacol Exp Ther. 2011 Mar;336(3):743-50. 3. Watabiki T, et al. Biol Pharm Bull. 2011;34(7):1105-8. View Related Products by Target TRP Channel |
| Molecular Formula | C29H31N3O2 |
|---|---|
| Molecular Weight | 453.586 |