1238689-36-5
1238689-36-5 structure
- Name: JNJ-42905343
- Chemical Name: JNJ-42905343
- CAS Number: 1238689-36-5
- Molecular Formula: C20H15FN4O4
- Molecular Weight: 394.362
- Create Date: 2020-01-11 18:06:50
- Modify Date: 2024-04-06 07:40:55
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JNJ-42905343 is a potent, selective, orally active prolyl hydroxylase (PHD) inhibitor with pKi of 8.07, 7.48 and 7.27 for PHD1, PHD2 and PHD3 respectively; stabilizes HIF1-α in a concentration-dependent fashion in HeLa cells (EC50=19.7 uM) and stimulates the release of EPO from Hep3B cells (EC50=20.3 uM); increases blood haemoglobin, mean corpuscular haemoglobin (MCH) and mean corpuscular volume (MCV), corrects functional iron deficiency and inflammation-induced anaemia in rats.
| Name | JNJ-42905343 |
|---|
| Description | JNJ-42905343 is a potent, selective, orally active prolyl hydroxylase (PHD) inhibitor with pKi of 8.07, 7.48 and 7.27 for PHD1, PHD2 and PHD3 respectively; stabilizes HIF1-α in a concentration-dependent fashion in HeLa cells (EC50=19.7 uM) and stimulates the release of EPO from Hep3B cells (EC50=20.3 uM); increases blood haemoglobin, mean corpuscular haemoglobin (MCH) and mean corpuscular volume (MCV), corrects functional iron deficiency and inflammation-induced anaemia in rats. |
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| References | References 1. Barrett TD, et al. Br J Pharmacol. 2015 Aug;172(16):4078-88. View Related Products by Target HIF/HIF Prolyl-hydroxylase |
| Molecular Formula | C20H15FN4O4 |
|---|---|
| Molecular Weight | 394.362 |