515846-21-6

515846-21-6 structure

Name: SP4206
Chemical Name: SP 4206
CAS Number: 515846-21-6
Molecular Formula: C₃₀H₃₇Cl₂N₇O₆
Molecular Weight: 662.57
Catalog: Signaling Pathways Immunology/Inflammation Interleukin Related
Create Date: 2020-01-11 16:29:51
Modify Date: 2024-01-29 18:43:26
SP 4206 is a high-affinity (Kd=70 nM) small molecule that blocks blocks the binding of the IL-2α receptor (IL-2Rα) to IL-2; targets virtually the same critical "hot-spot" residues on IL-2 that drive binding of IL-2Rα.

Name	SP 4206

Description	SP 4206 is a high-affinity (Kd=70 nM) small molecule that blocks blocks the binding of the IL-2α receptor (IL-2Rα) to IL-2; targets virtually the same critical "hot-spot" residues on IL-2 that drive binding of IL-2Rα.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology
Target	IL-2/IL-2Rα interaction[1]
In Vitro	SP4206 binds the WT IL-2, IL-2 variant K35L/M39V, IL-2 variant P65A, and IL-2 variant V69A with EC50s of 68.8, 80.1, 117.0, and 10.4 nM, respectively[1].
References	[1]. Thanos CD, et al. Hot-spot mimicry of a cytokine receptor by a small molecule. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15422-7.

Molecular Formula	C₃₀H₃₇Cl₂N₇O₆
Molecular Weight	662.57