2092352-48-0
2092352-48-0 structure
- Name: DS-2969b
- Chemical Name: DS-2969b
- CAS Number: 2092352-48-0
- Molecular Formula: C17H25ClN6O3S
- Molecular Weight: 428.936
- Create Date: 2020-01-12 10:01:49
- Modify Date: 2024-01-22 11:42:55
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DS-2969b (DS 11960558) is a novel orally active GyrB inhibitor, inhibits the supercoiling activity of C. difficile DNA gyrase with IC50 of 20 ng/mL; showes potent in vitro activity against C. difficile clinical isolates with MIC90 of 0.06 μg/mL, 2-, 32-, and 16-fold lower than the MIC90 of fidaxomicin, vancomycin, and metronidazole, respectively; demonstrates excellent in vivo activity against Clostridium difficile (CDI) model. Bacterial Infection Phase 1 Clinical
| Name | DS-2969b |
|---|
| Description | DS-2969b (DS 11960558) is a novel orally active GyrB inhibitor, inhibits the supercoiling activity of C. difficile DNA gyrase with IC50 of 20 ng/mL; showes potent in vitro activity against C. difficile clinical isolates with MIC90 of 0.06 μg/mL, 2-, 32-, and 16-fold lower than the MIC90 of fidaxomicin, vancomycin, and metronidazole, respectively; demonstrates excellent in vivo activity against Clostridium difficile (CDI) model. Bacterial Infection Phase 1 Clinical |
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| References | References 1. Mathur T, et al. Antimicrob Agents Chemother. 2018 Feb 12. pii: AAC.02157-17. 2. Vandell AG, et al. Antimicrob Agents Chemother. 2018 Feb 12. pii: AAC.02537-17. View Related Products by Target Bacterial Bacterial Infection |
| Molecular Formula | C17H25ClN6O3S |
|---|---|
| Molecular Weight | 428.936 |