1962178-27-3
1962178-27-3 structure
- Name: PF-04802367
- Chemical Name: PF-04802367
- CAS Number: 1962178-27-3
- Molecular Formula: C16H16ClN5O3
- Molecular Weight: 361.786
- Catalog: Signaling Pathways PI3K/Akt/mTOR GSK-3
- Create Date: 2020-01-12 08:22:49
- Modify Date: 2024-04-02 18:10:49
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A potent, highly selective GSK-3 inhibitor with IC50 of 2.1 nM for human GSK-3β in enzyme assays; shows equal effectivity against GSK-3α and GSK-3β with IC50 of 10.0 and 9.0 nM respectively in mobility shift assays, inhibits phosphorylation of tau with an IC50 of 466 nM in a stable inducible CHO cell line over-expressing GSK-3β and substrate tau; modulates tau phosphorylation in vitro and in vivo.
| Name | PF-04802367 |
|---|
| Description | A potent, highly selective GSK-3 inhibitor with IC50 of 2.1 nM for human GSK-3β in enzyme assays; shows equal effectivity against GSK-3α and GSK-3β with IC50 of 10.0 and 9.0 nM respectively in mobility shift assays, inhibits phosphorylation of tau with an IC50 of 466 nM in a stable inducible CHO cell line over-expressing GSK-3β and substrate tau; modulates tau phosphorylation in vitro and in vivo. |
|---|---|
| References | References 1. Liang SH, et al. Angew Chem Int Ed Engl. 2016 Aug 8;55(33):9601-5. View Related Products by Target GSK-3 |
| Molecular Formula | C16H16ClN5O3 |
|---|---|
| Molecular Weight | 361.786 |