1859189-54-0
1859189-54-0 structure
- Name: BNM-III-170
- Chemical Name: BNM-III-170
- CAS Number: 1859189-54-0
- Molecular Formula: C21H24ClFN6O2
- Molecular Weight: 446.911
- Create Date: 2020-01-11 17:17:25
- Modify Date: 2024-03-04 10:44:43
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BNM-III-170 is a small-molecule CD4-mimetic compound that enhances vaccine efficacy against HIV-1 challenge in vivo; binds the HIV-1 gp120 Env and promotes conformational changes similar to those induced by CD4, exposing conserved Env elements to antibodies; synergizes with antibodies elicited by monomeric HIV-1 gp120 to protect monkeys from multiple high-dose intrarectal challenges with a heterologous simian-human immunodeficiency virus (SHIV).
| Name | BNM-III-170 |
|---|
| Description | BNM-III-170 is a small-molecule CD4-mimetic compound that enhances vaccine efficacy against HIV-1 challenge in vivo; binds the HIV-1 gp120 Env and promotes conformational changes similar to those induced by CD4, exposing conserved Env elements to antibodies; synergizes with antibodies elicited by monomeric HIV-1 gp120 to protect monkeys from multiple high-dose intrarectal challenges with a heterologous simian-human immunodeficiency virus (SHIV). |
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| References | References 1. Madani N, et al. Nat Commun. 2018 Jun 18;9(1):2363. View Related Products by Target HIV |
| Molecular Formula | C21H24ClFN6O2 |
|---|---|
| Molecular Weight | 446.911 |