1852452-14-2
1852452-14-2 structure
- Name: PF-739
- Chemical Name: PF-739
- CAS Number: 1852452-14-2
- Molecular Formula: C23H23ClN2O5
- Molecular Weight: 442.896
- Catalog: Signaling Pathways Epigenetics AMPK
- Create Date: 2020-01-19 08:39:28
- Modify Date: 2024-04-09 19:17:08
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A novel potent, pan-AMPK activator with similar potency for all AMPK heterotrimers; increases the phosphorylation of the AMPK substrate ACC at S79 with EC50 of 121 nM, potently inhibits de novo lipogenesis (IC50=25 nM) in primary rat hepatocytes; increases PGC1a transcription and mitochondrial content, effectively activats AMPK in hepatocytes and in skeletal muscle; caused a rapid lowering of plasma glucose levels with no impact on hepatic glucose production in diabetic mice.
| Name | PF-739 |
|---|
| Description | A novel potent, pan-AMPK activator with similar potency for all AMPK heterotrimers; increases the phosphorylation of the AMPK substrate ACC at S79 with EC50 of 121 nM, potently inhibits de novo lipogenesis (IC50=25 nM) in primary rat hepatocytes; increases PGC1a transcription and mitochondrial content, effectively activats AMPK in hepatocytes and in skeletal muscle; caused a rapid lowering of plasma glucose levels with no impact on hepatic glucose production in diabetic mice. |
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| References | References 1. Cokorinos EC, et al. Cell Metab. 2017 May 2;25(5):1147-1159. View Related Products by Target AMPK |
| Molecular Formula | C23H23ClN2O5 |
|---|---|
| Molecular Weight | 442.896 |