1638140-55-2
1638140-55-2 structure
- Name: OTX008
- Chemical Name: OTX008
- CAS Number: 1638140-55-2
- Molecular Formula: C52H72N8O8
- Molecular Weight: 937.18
- Create Date: 2020-01-11 17:41:50
- Modify Date: 2025-09-04 20:40:24
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OTX008 (Calixarene 0118, PTX-008) is a calixarene derivative designed to bind the Galectin-1 (Gal1) amphipathic β-sheet conformation; inhibits Gal1 expression and ERK1/2 and AKT-dependent survival pathways, and induces G2/M cell cycle arrest through CDK1; inhibits proliferation and invasion at micromolar concentrations in cancer cells; inhibits growth of A2780-1A9 xenografts in vivo. Solid Tumors Phase 1 Clinical
| Name | OTX008 |
|---|
| Description | OTX008 (Calixarene 0118, PTX-008) is a calixarene derivative designed to bind the Galectin-1 (Gal1) amphipathic β-sheet conformation; inhibits Gal1 expression and ERK1/2 and AKT-dependent survival pathways, and induces G2/M cell cycle arrest through CDK1; inhibits proliferation and invasion at micromolar concentrations in cancer cells; inhibits growth of A2780-1A9 xenografts in vivo. Solid Tumors Phase 1 Clinical |
|---|---|
| References | References 1. Dings RP, et al. J Med Chem. 2012 Jun 14;55(11):5121-9. 2. Astorgues-Xerri L, et al. Eur J Cancer. 2014 Sep;50(14):2463-77. 3. Dings RP, et al. Cancer Lett. 2008 Jul 8;265(2):270-80. 4. Zucchetti M, et al. Cancer Chemother Pharmacol. 2013 Oct;72(4):879-87. View Related Products by Target Galectin Solid Tumors |
| Molecular Formula | C52H72N8O8 |
|---|---|
| Molecular Weight | 937.18 |