1592908-16-1

1592908-16-1 structure

Name: MSN-125
Chemical Name: MSN-125
CAS Number: 1592908-16-1
Molecular Formula: C₃₆H₃₈BrN₃O₆
Molecular Weight: 688.619
Catalog: Signaling Pathways Apoptosis Bcl-2 Family
Create Date: 2020-01-11 18:09:50
Modify Date: 2024-01-08 19:50:18
MSN-125 (MSN 125, MSN125) is a small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 4 uM; potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity.

Name	MSN-125

Description	MSN-125 (MSN 125, MSN125) is a small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 4 uM; potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity.
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer
Target	Bax Bak
In Vitro	MSN-125 inhibits tBid/Bax-mediated MOMP in a concentration-dependent manner[1].
References	[1]. Niu X, et al. A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell Chem Biol. 2017 Apr 20;24(4):493-506.e5.

Molecular Formula	C₃₆H₃₈BrN₃O₆
Molecular Weight	688.619

Hazard Codes	Xi