1211757-83-3
1211757-83-3 structure
- Name: MNKI-19
- Chemical Name: MNKI-19
- CAS Number: 1211757-83-3
- Molecular Formula: C17H16FN3O3S
- Molecular Weight: 361.391
- Create Date: 2020-01-12 12:16:50
- Modify Date: 2025-09-18 22:07:21
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MNKI-19 is a potent and dual-specific Mnk inhibitor with Ki of 186 nM and 68 nM for Mnk1 and Mnk2, respectively; only displays moderate activity against Pim-1 (Ki=2.35 uM) in a panel of upstream activating kinases of Mnks, including B-Raf, MAPK1, MAPK2, Akt1, PI3K, p38α, and mTOR; inhibits the phosphorylation of eIF4E and 4E-BP1, arrests cancer cells in the G1 phase and induce apoptosis in FLT3-ITD expressed AML cells.
| Name | MNKI-19 |
|---|
| Description | MNKI-19 is a potent and dual-specific Mnk inhibitor with Ki of 186 nM and 68 nM for Mnk1 and Mnk2, respectively; only displays moderate activity against Pim-1 (Ki=2.35 uM) in a panel of upstream activating kinases of Mnks, including B-Raf, MAPK1, MAPK2, Akt1, PI3K, p38α, and mTOR; inhibits the phosphorylation of eIF4E and 4E-BP1, arrests cancer cells in the G1 phase and induce apoptosis in FLT3-ITD expressed AML cells. |
|---|---|
| References | References 1. Teo T, et al. Mol Pharmacol. 2015 Aug;88(2):380-9. View Related Products by Target MNK |
| Molecular Formula | C17H16FN3O3S |
|---|---|
| Molecular Weight | 361.391 |