949080-24-4

949080-24-4 structure

Name: TRO 40303
Chemical Name: TRO-40303
CAS Number: 949080-24-4
Molecular Formula: C₂₆H₄₇NO₂
Molecular Weight: 405.657
Create Date: 2020-01-19 20:48:55
Modify Date: 2024-04-06 08:02:43
TRO 40303 is a novel cardioprotective compound that delays mitochondrial permeability transition pore (mPTP) opening, binds specifically to TSPO at the cholesterol site (Ki=150 nM); has no effect on the calcium retention capacity (CRC) of isolated mitochondria; causes significant reduction in reactive oxygen species production and subsequent calcium overload; reduces infarct size when administered before reperfusion in in vivo model.

Name	TRO-40303
Synonyms	TRO-40303 7H-Benz[e]inden-7-one, 3-[(1R)-1,5-dimethylhexyl]dodecahydro-6-(3-hydroxypropyl)-3a,6-dimethyl-, oxime, (3R,3aR,5aS,6R,7E,9aS,9bS)- 3W389841RN 3-{(3R,3aR,5aS,6R,7E,9aS,9bS)-7-(Hydroxyimino)-3a,6-dimethyl-3-[(2R)-6-methyl-2-heptanyl]dodecahydro-1H-cyclopenta[a]naphthalen-6-yl}-1-propanol

Description	TRO 40303 is a novel cardioprotective compound that delays mitochondrial permeability transition pore (mPTP) opening, binds specifically to TSPO at the cholesterol site (Ki=150 nM); has no effect on the calcium retention capacity (CRC) of isolated mitochondria; causes significant reduction in reactive oxygen species production and subsequent calcium overload; reduces infarct size when administered before reperfusion in in vivo model.
References	References 1. Schaller S, et al. J Pharmacol Exp Ther. 2010 Jun;333(3):696-706. 2. Le Lamer S, et al. J Transl Med. 2014 Feb 7;12:38. 3. Hansson MJ, et al. Eur J Pharmacol. 2015 Aug 5;760:7-19. View Related Products by Target Mitochondrial Permeability Transition Pore (mPTP)