402955-58-2
402955-58-2 structure
- Name: PF-03049423
- Chemical Name: Pf-03049423 Hydrochloride
- CAS Number: 402955-58-2
- Molecular Formula: C24H32N6O4
- Molecular Weight: 505.010
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
- Create Date: 2020-01-11 19:16:50
- Modify Date: 2024-01-14 17:59:12
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PF-03049423 is a potent, selective, orally active, and brain penetrant inhibitor of PDE5 with IC50 of 0.2 nM; displays 158-fold and 2460-fold selectivity over PDE6 and PDE11, respectively; possesses an excellent potency and selectivity profile and demonstrates robust in vivo blood pressure lowering in a spontaneously hypertensive rat (SHR) model. Stroke Phase 2 Discontinued
| Name | Pf-03049423 Hydrochloride |
|---|---|
| Synonyms |
Pf-03049423 Hydrochloride
3-[4-(2-Hydroxyethyl)-1-piperazinyl]-7-(6-methoxy-3-pyridinyl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one hydrochloride (1:1) Pyrido[3,4-b]pyrazin-2(1H)-one, 3-[4-(2-hydroxyethyl)-1-piperazinyl]-7-(6-methoxy-3-pyridinyl)-1-(2-propoxyethyl)-, hydrochloride (1:1) |
| Description | PF-03049423 is a potent, selective, orally active, and brain penetrant inhibitor of PDE5 with IC50 of 0.2 nM; displays 158-fold and 2460-fold selectivity over PDE6 and PDE11, respectively; possesses an excellent potency and selectivity profile and demonstrates robust in vivo blood pressure lowering in a spontaneously hypertensive rat (SHR) model. Stroke Phase 2 Discontinued |
|---|---|
| References | References 1. Hughes RO, et al. J Med Chem. 2010 Mar 25;53(6):2656-60. 2. Di Cesare F, et al. J Stroke Cerebrovasc Dis. 2016 Mar;25(3):642-9. View Related Products by Target Phosphodiesterase (PDE) Stroke |
| Molecular Formula | C24H32N6O4 |
|---|---|
| Molecular Weight | 505.010 |
| Exact Mass | 504.225189 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| RIDADR | NONH for all modes of transport |