351424-20-9
351424-20-9 structure
- Name: CBA
- Chemical Name: 4-Chloro-2-{[(2-chlorophenoxy)acetyl]amino}benzoic acid
- CAS Number: 351424-20-9
- Molecular Formula: C15H11Cl2NO4
- Molecular Weight: 340.158
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
- Create Date: 2020-01-11 15:25:55
- Modify Date: 2024-01-09 13:09:28
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TRPM4 inhibitor 5 is a potent and selective inhibitor of TRPM4 with IC50 of 1.5 uM (Na+ influx); selectively inhibits TRPM4 overexpressed in HEK293 cells (IC50=1.8 uM) using classical patch-clamp electrophysiology recordings, shows no significant effect on the TRPM5 current, as well as other TRP family members including TRPM7, TRPM8, TRPV1 and TRPV6.
| Name | 4-Chloro-2-{[(2-chlorophenoxy)acetyl]amino}benzoic acid |
|---|---|
| Synonyms |
Benzoic acid, 4-chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]-
4-Chloro-2-{[(2-chlorophenoxy)acetyl]amino}benzoic acid |
| Description | TRPM4 inhibitor 5 is a potent and selective inhibitor of TRPM4 with IC50 of 1.5 uM (Na+ influx); selectively inhibits TRPM4 overexpressed in HEK293 cells (IC50=1.8 uM) using classical patch-clamp electrophysiology recordings, shows no significant effect on the TRPM5 current, as well as other TRP family members including TRPM7, TRPM8, TRPV1 and TRPV6. |
|---|---|
| References | References 1. Ozhathil LC, et al. Br J Pharmacol. 2018 Jun;175(12):2504-2519. View Related Products by Target TRP Channel |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 576.4±50.0 °C at 760 mmHg |
| Molecular Formula | C15H11Cl2NO4 |
| Molecular Weight | 340.158 |
| Flash Point | 302.4±30.1 °C |
| Exact Mass | 339.006500 |
| LogP | 4.95 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.656 |