2115022-67-6
2115022-67-6 structure
- Name: PF-06827443
- Chemical Name: PF-06827443
- CAS Number: 2115022-67-6
- Molecular Formula: C24H24N2O4
- Molecular Weight: 404.458
- Catalog: Signaling Pathways GPCR/G Protein mAChR
- Create Date: 2020-01-20 08:38:57
- Modify Date: 2024-09-24 11:40:03
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PF-06827443 (PF06827443) is a potent, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with EC50 of 47 nM, shows no activity against M2-M5 at 10 uM; induces cholinergic adverse events and convulsion at therapeutic indices similar to previous compounds with more agonist activity.
| Name | PF-06827443 |
|---|---|
| Synonyms |
2-((3R,4S)-3-Hydroxytetrahydro-pyran-4-yl)-5-methyl-6-(4-oxazol-4-yl-benzyl)-2,3-dihydro-isoindol-1-one
PF-06827443 L-threo-Pentitol, 1,5-anhydro-2,3-dideoxy-3-[1,3-dihydro-5-methyl-6-[[4-(4-oxazolyl)phenyl]methyl]-1-oxo-2H-isoindol-2-yl]- 1,5-Anhydro-2,3-dideoxy-3-{5-methyl-6-[4-(1,3-oxazol-4-yl)benzyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-L-threo-pentitol |
| Description | PF-06827443 (PF06827443) is a potent, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with EC50 of 47 nM, shows no activity against M2-M5 at 10 uM; induces cholinergic adverse events and convulsion at therapeutic indices similar to previous compounds with more agonist activity. |
|---|---|
| References | References 1. Davoren JE, et al. J Med Chem. 2017 Aug 10;60(15):6649-6663. 2. Moran SP, et al. ACS Chem Neurosci. 2018 Apr 25. doi: 10.1021/acschemneuro.8b00106. View Related Products by Target mAChR |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 669.7±55.0 °C at 760 mmHg |
| Molecular Formula | C24H24N2O4 |
| Molecular Weight | 404.458 |
| Flash Point | 358.8±31.5 °C |
| Exact Mass | 404.173615 |
| LogP | 1.79 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.631 |