2036081-86-2

2036081-86-2 structure

Name: JNJ 55511118
Chemical Name: 5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one
CAS Number: 2036081-86-2
Molecular Formula: C₁₄H₈ClF₃N₂O₂
Molecular Weight: 328.674
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2020-01-11 18:12:33
Modify Date: 2024-04-05 17:46:52
JNJ-55511118 (JNJ55511118) is a selective, orally available AMPA receptor containing TARP-γ8 negative modulator with Ki of 26 nM, displays no significant activity against other TARP-less AMPARs and AMPARs coexpressed with other TARPs or CNIH2; demonstrates excellent pharmacokinetic properties and achieves high receptor occupancy following oral administration, exhibits a strong reduction in certain bands on electroencephalogram, transient hyperlocomotion, no motor impairment on rotarod, and a mild impairment in learning and memory in vivo.

Name	5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one
Synonyms	2H-Benzimidazol-2-one, 5-[2-chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro- 5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one

Description	JNJ-55511118 (JNJ55511118) is a selective, orally available AMPA receptor containing TARP-γ8 negative modulator with Ki of 26 nM, displays no significant activity against other TARP-less AMPARs and AMPARs coexpressed with other TARPs or CNIH2; demonstrates excellent pharmacokinetic properties and achieves high receptor occupancy following oral administration, exhibits a strong reduction in certain bands on electroencephalogram, transient hyperlocomotion, no motor impairment on rotarod, and a mild impairment in learning and memory in vivo.
References	References 1. Maher MP, et al. J Pharmacol Exp Ther. 2016 May;357(2):394-414. 2. Ravula S, et al. ACS Med Chem Lett. 2018 Jul 13;9(8):821-826. View Related Products by Target iGluR