1809581-87-0
1809581-87-0 structure
- Name: MM-206
- Chemical Name: MM 206
- CAS Number: 1809581-87-0
- Molecular Formula: C22H12F5NO3S2
- Molecular Weight: 497.458
- Catalog: Signaling Pathways JAK/STAT Signaling STAT
- Create Date: 2020-01-11 19:16:32
- Modify Date: 2024-01-13 06:59:28
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A novel small molecule STAT3 inhibitor that inhibits STAT3 DNA binding activity with IC50 of 1.16 uM, binds to the STAT3 coiled-coil domain (CCD); also inhibits G-CSF-induced STAT3 phosphorylation in AML cell lines with IC50 of 0.8-1.9 uM,
| Name | MM 206 |
|---|---|
| Synonyms |
MFCD30179936
Benzenesulfonamide, 2,3,4,5,6-pentafluoro-N-[4-hydroxy-3-(phenylthio)-1-naphthalenyl]- 2,3,4,5,6-Pentafluoro-N-(4-hydroxy-3-(phenylthio)naphthalen-1-yl)benzenesulfonamide 2,3,4,5,6-Pentafluoro-N-[4-hydroxy-3-(phenylsulfanyl)-1-naphthyl]benzenesulfonamide MM 206 MM-206 |
| Description | A novel small molecule STAT3 inhibitor that inhibits STAT3 DNA binding activity with IC50 of 1.16 uM, binds to the STAT3 coiled-coil domain (CCD); also inhibits G-CSF-induced STAT3 phosphorylation in AML cell lines with IC50 of 0.8-1.9 uM, |
|---|---|
| References | References 1. Minus MB, et al. Angew Chem Int Ed Engl. 2015 Oct 26;54(44):13085-9. View Related Products by Target STAT |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 601.9±65.0 °C at 760 mmHg |
| Molecular Formula | C22H12F5NO3S2 |
| Molecular Weight | 497.458 |
| Flash Point | 317.8±34.3 °C |
| Exact Mass | 497.017883 |
| LogP | 5.81 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.694 |