1620203-88-4
1620203-88-4 structure
- Name: ML398
- Chemical Name: ML398
- CAS Number: 1620203-88-4
- Molecular Formula: C19H22ClNO
- Molecular Weight: 315.837
- Create Date: 2020-01-11 20:03:50
- Modify Date: 2024-10-07 13:43:41
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ML398 (CID72737723) is a potent, selective, highly brain penetrant dopamine 4 (D4) receptor antagonist with IC50/Ki of 130 nM/60 nM; shows excellent selectivity (>100-fold) against the other dopamine receptor subtypes (D1,2S,2L,3,5; >20 uM); reverses cocaine-induced hyperlocomotion at 10 mg/kg in vivo.
| Name | ML398 |
|---|---|
| Synonyms |
ML398
(2R)-4-(4-Chlorobenzyl)-2-(2-phenylethyl)morpholine Morpholine, 4-[(4-chlorophenyl)methyl]-2-(2-phenylethyl)-, (2R)- |
| Description | ML398 (CID72737723) is a potent, selective, highly brain penetrant dopamine 4 (D4) receptor antagonist with IC50/Ki of 130 nM/60 nM; shows excellent selectivity (>100-fold) against the other dopamine receptor subtypes (D1,2S,2L,3,5; >20 uM); reverses cocaine-induced hyperlocomotion at 10 mg/kg in vivo. |
|---|---|
| References | References 1. Berry CB, et al. ACS Med Chem Lett. 2014 Jul 9;5(9):1060-4. View Related Products by Target Dopamine Receptor |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 421.3±30.0 °C at 760 mmHg |
| Molecular Formula | C19H22ClNO |
| Molecular Weight | 315.837 |
| Flash Point | 208.6±24.6 °C |
| Exact Mass | 315.138977 |
| LogP | 4.34 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.574 |