1560968-49-1
1560968-49-1 structure
- Name: ML399
- Chemical Name: 4-(3-{4-[(R)-(3-Fluorophenyl)(hydroxy)2-pyridinylmethyl]-1-piperidinyl}propoxy)benzonitrile
- CAS Number: 1560968-49-1
- Molecular Formula: C27H28FN3O2
- Molecular Weight: 445.529
- Create Date: 2020-01-12 04:38:59
- Modify Date: 2025-07-19 15:07:01
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ML399 (VU0516340) is a potent and cell penetrant menin-MLL inhibitor with IC50 of 90 nM; shows improved potency and DMPK properties; a chemical probe for in vivo proof-of-mechanism studies.
| Name | 4-(3-{4-[(R)-(3-Fluorophenyl)(hydroxy)2-pyridinylmethyl]-1-piperidinyl}propoxy)benzonitrile |
|---|---|
| Synonyms |
Benzonitrile, 4-[3-[4-[(R)-(3-fluorophenyl)hydroxy-2-pyridinylmethyl]-1-piperidinyl]propoxy]-
4-(3-{4-[(R)-(3-Fluorophenyl)(hydroxy)2-pyridinylmethyl]-1-piperidinyl}propoxy)benzonitrile |
| Description | ML399 (VU0516340) is a potent and cell penetrant menin-MLL inhibitor with IC50 of 90 nM; shows improved potency and DMPK properties; a chemical probe for in vivo proof-of-mechanism studies. |
|---|---|
| References | References 1. Senter T, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. 2. Senter T, et al. Bioorg Med Chem Lett. 2015 Jul 1;25(13):2720-5. View Related Products by Target Histone Methyltransferase (HMTase) |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 636.5±55.0 °C at 760 mmHg |
| Molecular Formula | C27H28FN3O2 |
| Molecular Weight | 445.529 |
| Flash Point | 338.8±31.5 °C |
| Exact Mass | 445.216553 |
| LogP | 4.17 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.625 |