1345019-64-8
1345019-64-8 structure
- Name: Thr-Asp-F-amidine
- Chemical Name: N-Acetyl-L-threonyl-L-α-aspartyl-N5-(2-fluoroethanimidoyl)-L-ornithinamide
- CAS Number: 1345019-64-8
- Molecular Formula: C17H29FN6O7
- Molecular Weight: 448.447
- Create Date: 2020-01-11 11:02:27
- Modify Date: 2024-01-11 10:45:29
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Thr-Asp-F-amidine (TDFA) is a highly potent, selective PAD4 (protein arginine deiminase 4) inhibitor with IC50 of 2.3 uM, displays ≥15-fold selectivity for PAD4 versus PAD1 and ≥50-fold versus PADs 2 and 3; active in cells and can be used to inhibit PAD4 activity in cellulo.
| Name | N-Acetyl-L-threonyl-L-α-aspartyl-N5-(2-fluoroethanimidoyl)-L-ornithinamide |
|---|---|
| Synonyms |
L-Ornithinamide, N-acetyl-L-threonyl-L-α-aspartyl-N5-(2-fluoro-1-iminoethyl)-
N-Acetyl-L-threonyl-L-α-aspartyl-N5-(2-fluoroethanimidoyl)-L-ornithinamide |
| Description | Thr-Asp-F-amidine (TDFA) is a highly potent, selective PAD4 (protein arginine deiminase 4) inhibitor with IC50 of 2.3 uM, displays ≥15-fold selectivity for PAD4 versus PAD1 and ≥50-fold versus PADs 2 and 3; active in cells and can be used to inhibit PAD4 activity in cellulo. |
|---|---|
| References | References 1. Jones JE, et al. ACS Chem Biol. 2012 Jan 20;7(1):160-5. View Related Products by Target Protein Arginine Deiminase (PAD) |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C17H29FN6O7 |
| Molecular Weight | 448.447 |
| Exact Mass | 448.208160 |
| LogP | -2.92 |
| Index of Refraction | 1.597 |