1215849-96-9
1215849-96-9 structure
- Name: FSC 231
- Chemical Name: (E)-ethyl 2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate
- CAS Number: 1215849-96-9
- Molecular Formula: C13H10Cl2N2O3
- Molecular Weight: 313.136
- Create Date: 2020-01-11 11:47:58
- Modify Date: 2025-08-25 16:50:50
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FSC 231 (FSC231) is the first, cell-permeable small-molecule inhibitor of PICK1 PDZ domain with Kd of 10.1 uM; inhibits the interaction between GluR2 and PICK1, accelerates recycling of pHluorin-tagged GluR2 in hippocampal neurons; blocks the expression of both long-term depression and long-term potentiation in rats and murine hippocampal neurons.
| Name | (E)-ethyl 2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate |
|---|---|
| Synonyms |
(E)-ethyl 2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate
Ethyl [(2E)-2-cyano-3-(3,4-dichlorophenyl)-2-propenoyl]carbamate Carbamic acid, N-[(2E)-2-cyano-3-(3,4-dichlorophenyl)-1-oxo-2-propen-1-yl]-, ethyl ester |
| Description | FSC 231 (FSC231) is the first, cell-permeable small-molecule inhibitor of PICK1 PDZ domain with Kd of 10.1 uM; inhibits the interaction between GluR2 and PICK1, accelerates recycling of pHluorin-tagged GluR2 in hippocampal neurons; blocks the expression of both long-term depression and long-term potentiation in rats and murine hippocampal neurons. |
|---|---|
| References | References 1. Thorsen TS, et al. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):413-8. 2. Qiu CY, et al. J Neuroinflammation. 2012 May 29;9:108. 3. Herbert LM, et al. Am J Physiol Cell Physiol. 2016 Mar 1;310(5):C390-400. View Related Products by Target Other Targets |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C13H10Cl2N2O3 |
| Molecular Weight | 313.136 |
| Exact Mass | 312.006836 |
| LogP | 3.26 |
| Index of Refraction | 1.594 |