1019158-02-1
1019158-02-1 structure
- Name: iST2-1
- Chemical Name: 2-(4-Methoxyphenyl)-1-{[5-(2-nitrophenyl)-2-furyl]methyl}pyrrolidine
- CAS Number: 1019158-02-1
- Molecular Formula: C22H22N2O4
- Molecular Weight: 378.421
- Create Date: 2020-01-14 18:15:09
- Modify Date: 2023-01-11 14:58:31
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iST2-1 is a first-in-class, in vivo active ST2 (suppression of tumorigenicity 2) inhibitor with IC50 of 56.14 and 54.62 uM in AlphaLISA and the HEK-Blue IL-33 assay, respectively; decrease IFN-γ-producing T cell populations in the in vitro mixed lymphocyte reaction assays, reduces plasma sST2 levels, alleviate GVHD, and improve survival in vivo, ameliorates GVHD burden and maintains GVL effect in the murine MLL-AF9 leukemia model.
| Name | 2-(4-Methoxyphenyl)-1-{[5-(2-nitrophenyl)-2-furyl]methyl}pyrrolidine |
|---|---|
| Synonyms |
2-(4-Methoxyphenyl)-1-{[5-(2-nitrophenyl)-2-furyl]methyl}pyrrolidine
Pyrrolidine, 2-(4-methoxyphenyl)-1-[[5-(2-nitrophenyl)-2-furanyl]methyl]- MFCD14826567 |
| Description | iST2-1 is a first-in-class, in vivo active ST2 (suppression of tumorigenicity 2) inhibitor with IC50 of 56.14 and 54.62 uM in AlphaLISA and the HEK-Blue IL-33 assay, respectively; decrease IFN-γ-producing T cell populations in the in vitro mixed lymphocyte reaction assays, reduces plasma sST2 levels, alleviate GVHD, and improve survival in vivo, ameliorates GVHD burden and maintains GVL effect in the murine MLL-AF9 leukemia model. |
|---|---|
| References | References 1. Ramadan AM, et al. JCI Insight. 2018 Jul 25;3(14). pii: 99208. View Related Products by Target Other Targets |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 500.5±50.0 °C at 760 mmHg |
| Molecular Formula | C22H22N2O4 |
| Molecular Weight | 378.421 |
| Flash Point | 256.5±30.1 °C |
| Exact Mass | 378.157959 |
| LogP | 4.04 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.607 |
| Storage condition | 2-8°C |