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936339-60-5

936339-60-5 structure
936339-60-5 structure
  • Name: APX001
  • Chemical Name: E1210
  • CAS Number: 936339-60-5
  • Molecular Formula: C21H18N4O2
  • Molecular Weight: 358.393
  • Catalog: Signaling Pathways Anti-infection Fungal
  • Create Date: 2020-01-11 17:42:58
  • Modify Date: 2024-04-02 12:02:10
  • APX001 (APX 001A;E1210) is a novel broad-spectrum antifungal agent that inhibits the fungal protein Gwt1, demonstrates significantly acitive MIC50 and MIC90 values of 0.004 and 0.031 ug/ml (16 strains of C. auris); inhibits the inositol acylation activity of C. albicans Gwt1p and A. fumigatus Gwt1p with IC50 of 0.3 to 0.6 uM but has no inhibitory activity against human Pig-Wp; shows significant efficacy in murine model of disseminated C. auris infection, and log reduction in CFU counts in kidney, lung, and brain tissue. Fungal Infection Phase 1 Clinical

Name E1210
Synonyms 7B1P18ID9L
E1210
E-1210
3-(3-{4-[(2-Pyridinyloxy)methyl]benzyl}-1,2-oxazol-5-yl)-2-pyridinamine
2-Pyridinamine, 3-[3-[[4-[(2-pyridinyloxy)methyl]phenyl]methyl]-5-isoxazolyl]-
Description APX001 (APX 001A;E1210) is a novel broad-spectrum antifungal agent that inhibits the fungal protein Gwt1, demonstrates significantly acitive MIC50 and MIC90 values of 0.004 and 0.031 ug/ml (16 strains of C. auris); inhibits the inositol acylation activity of C. albicans Gwt1p and A. fumigatus Gwt1p with IC50 of 0.3 to 0.6 uM but has no inhibitory activity against human Pig-Wp; shows significant efficacy in murine model of disseminated C. auris infection, and log reduction in CFU counts in kidney, lung, and brain tissue. Fungal Infection Phase 1 Clinical
References References 1. Hager CL, et al. Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02319-17. 2. Zhao M, et al. Antimicrob Agents Chemother. 2018 Jan 29. pii: AAC.02542-17. 3. Watanabe NA, et al. Antimicrob Agents Chemother. 2012 Feb;56(2):960-71. 4. Miyazaki M, et al. Antimicrob Agents Chemother. 2011 Oct;55(10):4652-8. View Related Products by Target Fungal Fungal Infection
Density 1.3±0.1 g/cm3
Boiling Point 569.4±45.0 °C at 760 mmHg
Molecular Formula C21H18N4O2
Molecular Weight 358.393
Flash Point 298.1±28.7 °C
Exact Mass 358.142975
LogP 3.75
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.640
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