831234-13-0
831234-13-0 structure
- Name: AC 1903
- Chemical Name: 1-Benzyl-N-(2-furylmethyl)-1H-benzimidazol-2-amine
- CAS Number: 831234-13-0
- Molecular Formula: C19H17N3O
- Molecular Weight: 303.358
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
- Create Date: 2020-01-11 17:53:27
- Modify Date: 2025-08-24 07:17:02
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AC1903 is a potent, specific TRPC5 channel inhibitor with IC50 of 14.7 uM; blocks riluzole-activated TRPC5 whole-cell current, but fails to block carbachol (CCh)-induced TRPC4 and OAG-induced TRPC6 currents, even at high micromolar concentrations; pecifically blocks TRPC5 channel activity in glomeruli of proteinuric rats, suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of FSGS.
| Name | 1-Benzyl-N-(2-furylmethyl)-1H-benzimidazol-2-amine |
|---|---|
| Synonyms |
1H-Benzimidazol-2-amine, N-(2-furanylmethyl)-1-(phenylmethyl)-
MFCD06609959 1-Benzyl-N-(2-furylmethyl)-1H-benzimidazol-2-amine |
| Description | AC1903 is a potent, specific TRPC5 channel inhibitor with IC50 of 14.7 uM; blocks riluzole-activated TRPC5 whole-cell current, but fails to block carbachol (CCh)-induced TRPC4 and OAG-induced TRPC6 currents, even at high micromolar concentrations; pecifically blocks TRPC5 channel activity in glomeruli of proteinuric rats, suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of FSGS. |
|---|---|
| References | References 1. Zhou Y, et al. Science. 2017 Dec 8;358(6368):1332-1336. View Related Products by Target TRP Channel |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 512.4±60.0 °C at 760 mmHg |
| Molecular Formula | C19H17N3O |
| Molecular Weight | 303.358 |
| Flash Point | 263.7±32.9 °C |
| Exact Mass | 303.137177 |
| LogP | 4.23 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.648 |
| Hazard Codes | Xi |
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