693241-54-2
693241-54-2 structure
- Name: EG1
- Chemical Name: 2-({4-[(2-Methoxybenzoyl)amino]benzoyl}amino)benzoic acid
- CAS Number: 693241-54-2
- Molecular Formula: C22H18N2O5
- Molecular Weight: 390.389
- Catalog: Research Areas Cancer
- Create Date: 2020-01-12 10:22:13
- Modify Date: 2024-01-11 16:43:47
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Pax2 inhibitor EG1 (EG1) is a potent, small molecule inhibitor of Pax2 mediated transcription activation, effectively blocks Pax2 activity and DNA binding with Kd of 1.35-1.5 uM; inhibits Pax2 mediated expression with IC50 of 10 uM, and inhibits proliferation of Pax2 positive renal and ovarian cancer cell lines but has little effect on Pax2 negative cancer cells; inhibits embryonic kidney development.
| Name | 2-({4-[(2-Methoxybenzoyl)amino]benzoyl}amino)benzoic acid |
|---|---|
| Synonyms |
2-({4-[(2-Methoxybenzoyl)amino]benzoyl}amino)benzoic acid
Benzoic acid, 2-[[4-[(2-methoxybenzoyl)amino]benzoyl]amino]- |
| Description | Pax2 inhibitor EG1 (EG1) is a potent, small molecule inhibitor of Pax2 mediated transcription activation, effectively blocks Pax2 activity and DNA binding with Kd of 1.35-1.5 uM; inhibits Pax2 mediated expression with IC50 of 10 uM, and inhibits proliferation of Pax2 positive renal and ovarian cancer cell lines but has little effect on Pax2 negative cancer cells; inhibits embryonic kidney development. |
|---|---|
| References | References 1. Grimley E, et al. ACS Chem Biol. 2017 Mar 17;12(3):724-734. View Related Products by Target Other Targets |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 490.9±40.0 °C at 760 mmHg |
| Molecular Formula | C22H18N2O5 |
| Molecular Weight | 390.389 |
| Flash Point | 250.7±27.3 °C |
| Exact Mass | 390.121582 |
| LogP | 3.98 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.695 |
| Hazard Codes | Xi |
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