373370-73-1

373370-73-1 structure

Name: MitoBloCK 1
Chemical Name: (2E)-2-[(3-Bromo-2-hydroxy-6,7,8,9-tetrahydrodibenzo[b,d]furan-1-yl)methylene]hydrazinecarbothioamide
CAS Number: 373370-73-1
Molecular Formula: C₁₄H₁₄BrN₃O₂S
Molecular Weight: 368.249
Create Date: 2020-01-20 09:21:57
Modify Date: 2024-09-18 18:22:55
MitoBloCK 1 is a small molecule inhibitor that blocks the import of substrates that use the TIM22 import pathway, but not TIM23 or the Mia40/Erv1 translocation pathways; also inhibits growth of mammalian cells and import of the ADP/ATP carrier, but not TIM23 substrates; an useful chemical tool for investigation mammalian mitochondrial import and dysfunction linked to inherited human disease.

Name	(2E)-2-[(3-Bromo-2-hydroxy-6,7,8,9-tetrahydrodibenzo[b,d]furan-1-yl)methylene]hydrazinecarbothioamide
Synonyms	Hydrazinecarbothioamide, 2-[(3-bromo-6,7,8,9-tetrahydro-2-hydroxy-1-dibenzofuranyl)methylene]-, (2E)- (2E)-2-[(3-Bromo-2-hydroxy-6,7,8,9-tetrahydrodibenzo[b,d]furan-1-yl)methylene]hydrazinecarbothioamide

Description	MitoBloCK 1 is a small molecule inhibitor that blocks the import of substrates that use the TIM22 import pathway, but not TIM23 or the Mia40/Erv1 translocation pathways; also inhibits growth of mammalian cells and import of the ADP/ATP carrier, but not TIM23 substrates; an useful chemical tool for investigation mammalian mitochondrial import and dysfunction linked to inherited human disease.
References	References 1. Hasson SA, et al. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9578-83. View Related Products by Target Other Targets